Capsaicin CAS NO.404-86-4

Product Name:	Capsaicin
Synonyms:	(E)-8-METHYL-NON-6-ENOIC ACID 4-HYDROXY-3-METHOXY-BENZYLAMIDE;(E)-CAPSAICIN;(E)-N-([4-HYDROXY-3-METHOXYPHENYL]METHYL)8-METHYL-6-NONEAMIDE;(E)-N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6-NONENAMIDE;CAPSAICIN;CAPSAICINE;CAPSAICIN, NATURAL;FEMA 3404
CAS:	404-86-4
MF:	C18H27NO3
MW:	305.41
EINECS:	206-969-8
Product Categories:	INORGANIC & ORGANIC CHEMICALS;Anilines, Aromatic Amines and Nitro Compounds;Miscellaneous Natural Products;Natural Plant Extract;Intermediates & Fine Chemicals;Pharmaceuticals;Vanilloid/TRPV channel;Amines;Aromatics;Alkaloid;Amides;Bioactive Small Molecules;Building Blocks;Carbonyl Compounds;C-CH;Cell Biology;Chemical Synthesis;Nutrition Research;Organic Building Blocks;Phytochemicals by Chemical Classification;Phytochemicals by Plant (Food/Spice/Herb);Zingiber officinale (Ginger);API;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;NEURELAN;natural product;food additive;Inhibitors

Capsaicin Chemical Properties

mp	62-65 °C(lit.)
bp	210-220 C
FEMA	3404
Fp	113 °C
storage temp.	2-8°C
solubility	H₂O: insoluble
Water Solubility	insoluble
Merck	1768
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	404-86-4(CAS DataBase Reference)
EPA Substance Registry System	6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl) methyl]-8-methyl-, (6E)-(404-86-4)

Safety Information

Capsaicin Usage And Synthesis

Chemical Properties	Off-White Crystalline Solid
Usage	A representative lot is a 5:1 E:Z mixture. It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic.
Usage	K channel blocker; multiple sclerosis therapy
Usage	analgesic (topical), depletes Substance P, neurotoxic
Usage	Capsaicin analogue (C175680). It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic.
Usage	Capsaicin is used in many topical ointments used to relieve the pain of peripheral neuropathy (treatment of pain in the nerve endings near the surface of the skin).
Biological Activity	Prototypic vanilloid receptor agonist (pEC 50 values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of primary afferent sensory neurons, with subsequent antinociceptive and anti-inflammatory effects. Reversibly inhibits aggregation of platelets. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .