China (Mainland)
Tretinoin CAS NO.302-79-4
- Min.Order: 10 Gram
- Payment Terms: T/T,Other
- Product Details
Keywords
- Tretinoin
- 302-79-4,chemical
- research,C20H28O2
Quick Details
- ProName: Tretinoin
- CasNo: 302-79-4
- Molecular Formula: C20H28O2
- Appearance: Solid
- Application: Orally active estrogenic steroid. It w...
- DeliveryTime: 3days
- PackAge: in foil bag or customized
- Port: Tianjin xingang
- ProductionCapacity: 10 Kilogram/Week
- Purity: 99%
- Storage: Refrigerator
- Transportation: shipping by courier or by sea
- LimitNum: 10 Gram
Superiority
| Product Name: | Tretinoin |
| Synonyms: | TRETINOIN;TRETINOIN VITAMIN A ACID;TRANS-RETINOIC ACID;TRANS VITAMIN A ACID;VITAMIN A ACID;VITAMIN A ACID, ALL-TRANS;RETINOIC ACID;RETINOIC ACID, ALL TRANS |
| CAS: | 302-79-4 |
| MF: | C20H28O2 |
| MW: | 300.44 |
| EINECS: | 206-129-0 |
| Product Categories: | PHARMACEUTICALS;Active Pharmaceutical Ingredients;APIs;Biochemistry;Terpenes;Terpenes (Others);Vitamins;Intermediates & Fine Chemicals;Retinoids;Intracellular receptor;API;intermediates;Inhibitors |
Details
| Tretinoin Usage And Synthesis |
| Dermatology drugs | Tretinoin is commonly used in dermatology drugs, which is the department of vitamin A (Victoria methanol) metabolic intermediates.It mainly affects the growth of bones and epithelial metabolism, can promote epithelial cell proliferation and updates, and can inhibit the proliferation and differentiation of keratinocytes, so hyperkeratosis can be back to normal. Therefore many complete or incomplete keratosis, hyperkeratosis of diseases have a certain therapeutic effect, treat a variety of skin diseases. The use of the drug can penetrate topical skin quickly, enable significantly increased epithelial cell turnover. This class of drugs has strong and rapid inhibition on the secretion of the sebaceous glands, can reduce sebum secretion. In addition, the product also has anti-tumor, promote wound healing and anti-inflammatory effects. |
| Clinical application |
Tretinoin is mainly used in the treatment of psoriasis, ichthyosis, follicular keratosis, acne, lichen planus, verrucous epidermal nevus, impetigo, vitiligo, lichen psoriasis, the face of pityriasis alba, etc. In addition, the drugs also have some preventive effect on skin cancer. Tretinoin Cream |
| Physicochemical property |
It is a yellow needle crystal, with a similar smell of vitamin acetate. Soluble in methanol, ethanol, acetone, chloroform, dichloromethane , also in vegetable oil and fatty. In case of light, it is thermal instability, suck up moisture in the air, polymerization and metamorphism in water. The melting point of all trans-vitamin A acid is 182 ~ 180°C, the melting range of which is mixed with a small amount of isomers is 170 ~ 190°C. Tretinoin structure |
| Pharmacological action | This product can induce epidermal hyperplasia, and improve the granular layer and the cell layer thickness.It can influence the silk protein process and the formation of cross-linked film and promote the differentiation of epidermal granular layer cells in the late stage of the differentiation of the epidermal cells by affecting K10, K1 keratin solution. This product can significantly inhibit the formation of experimental acne, prevent and eliminate acne lesions. Tretinoin also affect melanocyte cell melanogenesis , it has more than a number of functional points, having inhibitory effect on the activity of Tyrosine hydroxylase, dopa oxidase and two hydroxyindole oxidase three catalyzing enzyme, so as to reduce the formation of melanin, reduce skin pigmentation. It has no effect on the normal black prime cellular tyrosinase activity and black pigment composition. |