China (Mainland)
Ubidecarenone 303-98-0 CAS NO.303-98-0
- Min.Order: 1 Kilogram
- Payment Terms: L/C,T/T,
- Product Details
Keywords
- Ubidecarenone
- COQ10;COENZYME Q10
- 303-98-0
Quick Details
- ProName: Ubidecarenone 303-98-0
- CasNo: 303-98-0
- Molecular Formula: C59H90O4
- Appearance: Yellow or orange yellow crystalline po...
- Application: Coenzyme medicines. It is also an impo...
- DeliveryTime: 12days
- PackAge: in bags or customized
- Port: Tianjin xingang
- ProductionCapacity: 10 Metric Ton/Day
- Purity: 99%
- Transportation: by sea
- LimitNum: 1 Kilogram
- Heavy metal: less than 0.4%
- Grade: Industrial Grade
Superiority
Our company is a professional chemical raw materials manufacturer and exporter for many years in chemical market. There are more than 200 excellent staffs and four factories working for us .
Company advantage:
1.Place of Origin in China with Super quality by reasonable price.
2.Fast delivery by safe express way to address specified.
3.Lots of highly qualified engineers and experts to provide technical guideness and support for customers.
4. Sample order are welcome.
5.A variety of payments, such as L/C, TT, , MoneyGram or other payments.
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Details
| Chemical Properties | Yellow or orange yellow crystalline powder; odorless and tasteless; case of light easily decomposed. |
| Application |
1. Coenzyme medicines. It is also an important antioxidant and immune enhancer. For congestive heart failure, arrhythmias, sinus tachycardia, premature beats, hypertension and cancer adjuvant therapy for acute and chronic viral hepatitis and subacute hepatic necrosis comprehensive treatment. In addition, it is also tested in primary and secondary aldosteronism, cerebrovascular disorders and hemorrhagic shock. during the application, user may appear nausea, upset stomach, loss of appetite and other phenomena, urticaria, and a transient palpitations occasionally appear. 2. Cardiovascular medicine. 3. It can be widely used in food, cosmetics, dietary supplements and other industries. Coenzyme drugs, is also an important antioxidant and immune enhancer. 4. It can activate human cells and cellular energy nutrition, it can improve human immunity, enhance anti-oxidation, anti-aging and enhance human activity. In addition, recent studies indicate that the product also has anti-tumor effects, for advanced metastatic cancer have a certain effect in clinical, have a significant effect in the prevention of coronary heart disease, alleviate periodontitis, treatment of duodenal and gastric ulcer, strengthen the immune system function and relieve angina . Because Ubidecarenone is effective and without side effects. It is used in pharmaceuticals, cosmetics, food additives and other industries. |
| Production method |
The residue was extracted from pig heart after the extraction of cytochrome C. Proceeding as follows: pig heart residues [saponification] saponification liquid [extract] extract [concentration, filtration] concentrate [adsorption] [washing] [eluted] eluent [concentrated] yellow oil [crystalline] [dried] Ubidecarenone from fresh pig heart extract 60.9mg per kilogram of Ubidecarenone. It may also be produced by fermentation. U.S. Patents 3068295,389153 and 4062879 describe the synthesis route of Ubidecarenone. Preparation of the drug substance Method One, alcohol - alkali saponification Preparation of Saponification: to take the pig heart residues, pressed dry weight, according to the weight of the dry residue add 300g / L Industrial Coke sexual gallic acid, stirring, add alcohol - alkaline solution (dry residue weight 3-3.5 times the amount of ethanol, 320g / L sodium hydroxide), was heated under reflux with stirring 25-30min, rapidly cooled to room temperature, the liquid was saponified. Pig heart residues [NaOH] → [Coke sexual gallic acid, ethanol] saponification solution Preparation of concentrate liquid: to take saponification liquid, immediately added 1/10 volume of petroleum ether or 120 petrol to extract 3-4 times, stirring, layered to give the extract. Washed with water to nearly neutral, concentrated to 1/10 of the original volumevbelow 40 ℃, cooled and allowed to stand overnight at less -5 ℃, filtration, concentrate. Saponification solution [petroleum] → extract [<40 ℃] → concentrate Preparation of Ubidecarenone: refined products, the concentrate was subjected to silica gel column chromatography, eluting with petroleum ether, 10% ethyl ether - petroleum ether eluate, solvent recovery, a yellow oil. Ethanol heating dissolved, filtered, and the filtrate was allowed to stand, cooling and crystallization, vacuum drying, Ubidecarenone refined products. v Concentrate [silica gel, ether - petroleum ether] → eluent [ethanol] → Ubidecarenone refined products Method two, alcohol - ether mixed solvent extraction Preparation of the Ubidecarenone crude product: pig heart residue is taken followed by a 1.5-fold amount of ethanol, V: V ether = 3: 1 mixed solvent, heat extraction 3-4 times, each time 15-20min, cooled to room temperature, filtered, and combined the extracts . Concentrated, added water, extracted with petroleum ether , the extraction was concentrated and the yellow oil concentration is Ubidecarenone crude product. Preparation of the finished Ubidecarenone product: Ubidecarenone crude product was dissolved in acetone, set at -10 ℃ to precipitate impurities, filtrated, the filtration was evaporated acetone, added a small amount of petroleum ether to dissolve, silica gel column chromatography, add ethanol crystallized to give Ubidecarenone products. Ubidecarenone crude product [silica gel] → [acetone, ethanol] finished Ubidecarenone Method three, bovine heart slags Bovine Heart residue [10% NaOH-80% ethanol] → brown-black solution [extract] → gasoline extract [washing] → orange butter layer [concentrated] → Ubidecarenone crude product [fat analysis] → clear oil [chromatography] Ubidecarenone → eluent [frozen concentrated to] → orange oil [crystalline sulfate] → finished Ubidecarenone Injection Characters: this product is a yellow clear liquid, with the extension of storage time, there will be precipitated orange, can be set at hot water heating for several minutes, shaking to dissolve, without affecting efficacy. The crystal is less stable, placed for 3-6 months, the concentration decreased about 3% -5%, up to more than 8%, but over time, the concentration decreasing rate will slow along time. Preparation: this product is sterile aqueous solution prepared by Ubidecarenone plus Tween-80 or other cosolvent . |
| Chemical Properties | Yellow-Orange Crystalline Powder |
| Usage | antioxidant, cardiovascular agent |
| Usage | Antibacterial and antioxidant for preventing and treating cancer. |
| Usage | A mitochondrial transporter chain component |
| Usage | Antibacterial, antioxidant |
| Biological Activity | Component of the mitochondrial transporter chain that behaves as a powerful antioxidant. Displays neuroprotective activity. |